Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Mycolic acids and multimethyl-branched fatty acids are found uniquely in the cell envelope of pathogenic mycobacteria. These unusually long fatty acids are essential for the survival, virulence, and antibiotic resistance of Mycobacterium tuberculosis. Acyl-CoA carboxylases (ACCases) commit acyl-CoAs...

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Detalhes bibliográficos
Main Authors: Lin, Ting-Wan, Melgar, Melrose M., Kurth, Daniel, Swamidass, S. Joshua, Purdon, John, Tseng, Teresa, Gago, Gabriela, Baldi, Pierre, Gramajo, Hugo, Tsai, Shiou-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413898/
https://ncbi.nlm.nih.gov/pubmed/16492739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510580103
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