Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Mycolic acids and multimethyl-branched fatty acids are found uniquely in the cell envelope of pathogenic mycobacteria. These unusually long fatty acids are essential for the survival, virulence, and antibiotic resistance of Mycobacterium tuberculosis. Acyl-CoA carboxylases (ACCases) commit acyl-CoAs...

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Hlavní autoři: Lin, Ting-Wan, Melgar, Melrose M., Kurth, Daniel, Swamidass, S. Joshua, Purdon, John, Tseng, Teresa, Gago, Gabriela, Baldi, Pierre, Gramajo, Hugo, Tsai, Shiou-Chuan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413898/
https://ncbi.nlm.nih.gov/pubmed/16492739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510580103
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