Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Mycolic acids and multimethyl-branched fatty acids are found uniquely in the cell envelope of pathogenic mycobacteria. These unusually long fatty acids are essential for the survival, virulence, and antibiotic resistance of Mycobacterium tuberculosis. Acyl-CoA carboxylases (ACCases) commit acyl-CoAs...

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Bibliografski detalji
Glavni autori: Lin, Ting-Wan, Melgar, Melrose M., Kurth, Daniel, Swamidass, S. Joshua, Purdon, John, Tseng, Teresa, Gago, Gabriela, Baldi, Pierre, Gramajo, Hugo, Tsai, Shiou-Chuan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413898/
https://ncbi.nlm.nih.gov/pubmed/16492739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510580103
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