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First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate
The cartilaginous fish are the oldest phylogenetic group in which Igs have been found. Sharks produce a unique Ig isotype, IgNAR, a heavy-chain homodimer that does not associate with light chains. Instead, the variable (V) regions of IgNAR bind antigen as soluble single domains. Our group has shown...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413636/ https://ncbi.nlm.nih.gov/pubmed/16446445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508341103 |
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