Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex

The membrane-bound form of Fas ligand (FasL) signals apoptosis in target cells through engagement of the death receptor Fas, whereas the proteolytically processed, soluble form of FasL does not induce cell death. However, soluble FasL can be rendered active upon cross-linking. Since the minimal exte...

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Bibliografiska uppgifter
Huvudupphovsmän: Holler, Nils, Tardivel, Aubry, Kovacsovics-Bankowski, Magdalena, Hertig, Sylvie, Gaide, Olivier, Martinon, Fabio, Tinel, Antoine, Deperthes, David, Calderara, Silvio, Schulthess, Therese, Engel, Jürgen, Schneider, Pascal, Tschopp, Jürg
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC141146/
https://ncbi.nlm.nih.gov/pubmed/12556501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.4.1428-1440.2003
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