Identification of a TAP-Independent, Immunoproteasome-Dependent CD8(+) T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2

We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but un...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lautscham, Georg, Haigh, Tracey, Mayrhofer, Sabine, Taylor, Graham, Croom-Carter, Debbie, Leese, Alison, Gadola, Stephan, Cerundolo, Vincenzo, Rickinson, Alan, Blake, Neil
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141109/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12552018/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.4.2757-2761.2003
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