Identification of a TAP-Independent, Immunoproteasome-Dependent CD8(+) T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2

We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but un...

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Autores principales: Lautscham, Georg, Haigh, Tracey, Mayrhofer, Sabine, Taylor, Graham, Croom-Carter, Debbie, Leese, Alison, Gadola, Stephan, Cerundolo, Vincenzo, Rickinson, Alan, Blake, Neil
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC141109/
https://ncbi.nlm.nih.gov/pubmed/12552018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2757-2761.2003
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