Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells

INTRODUCTION: CCN6/WISP3 belongs to the CCN (Cyr61, CTGF, Nov) family of genes that contains a conserved insulin-like growth factor (IGF) binding protein motif. CCN6 is a secreted protein lost in 80% of the aggressive inflammatory breast cancers, and can decrease mammary tumor growth in vitro and in...

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Hauptverfasser: Zhang, Yanhong, Pan, Quintin, Zhong, Hui, Merajver, Sofia D, Kleer, Celina G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2005
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1410771/
https://ncbi.nlm.nih.gov/pubmed/16457688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1351
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