Modification of the 5′ Terminus of Sindbis Virus Genomic RNA Allows nsP4 RNA Polymerases with Nonaromatic Amino Acids at the N Terminus To Function in RNA Replication

We have previously shown that Sindbis virus RNA polymerase requires an N-terminal aromatic amino acid or histidine for wild-type or pseudo-wild-type function; mutant viruses with a nonaromatic amino acid at the N terminus of the polymerase, but which are otherwise wild type, are unable to produce pr...

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Pubblicato in:	J Virol
Autori principali:	Shirako, Yukio, Strauss, Ellen G., Strauss, James H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141077/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12551967/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.4.2301-2309.2003
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