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Modification of the 5′ Terminus of Sindbis Virus Genomic RNA Allows nsP4 RNA Polymerases with Nonaromatic Amino Acids at the N Terminus To Function in RNA Replication

We have previously shown that Sindbis virus RNA polymerase requires an N-terminal aromatic amino acid or histidine for wild-type or pseudo-wild-type function; mutant viruses with a nonaromatic amino acid at the N terminus of the polymerase, but which are otherwise wild type, are unable to produce pr...

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Detalhes bibliográficos
Main Authors: Shirako, Yukio, Strauss, Ellen G., Strauss, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC141077/
https://ncbi.nlm.nih.gov/pubmed/12551967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2301-2309.2003
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