Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis

The role of activated microglia (MG) in demyelinating neurodegenerative diseases such as multiple sclerosis is controversial. Here we show that high, but not low, levels of IFN-γ (a cytokine associated with inflammatory autoimmune diseases) conferred on rodent MG a phenotype that impeded oligodendro...

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Detalhes bibliográficos
Main Authors: Butovsky, Oleg, Landa, Gennady, Kunis, Gilad, Ziv, Yaniv, Avidan, Hila, Greenberg, Nadav, Schwartz, Adi, Smirnov, Igor, Pollack, Ayala, Jung, Steffen, Schwartz, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409740/
https://ncbi.nlm.nih.gov/pubmed/16557302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26836
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