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Positive and negative regulation of APP amyloidogenesis by sumoylation
Amyloid β peptide (Aβ) generated from amyloid precursor protein (APP) is central to Alzheimer's disease (AD). Signaling pathways affecting APP amyloidogenesis play critical roles in AD pathogenesis and can be exploited for therapeutic intervention. Here, we show that sumoylation, covalent modif...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140945/ https://ncbi.nlm.nih.gov/pubmed/12506199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0235361100 |
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