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Positive and negative regulation of APP amyloidogenesis by sumoylation
Amyloid β peptide (Aβ) generated from amyloid precursor protein (APP) is central to Alzheimer's disease (AD). Signaling pathways affecting APP amyloidogenesis play critical roles in AD pathogenesis and can be exploited for therapeutic intervention. Here, we show that sumoylation, covalent modif...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140945/ https://ncbi.nlm.nih.gov/pubmed/12506199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0235361100 |
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