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Alphavirus Minus-Strand Synthesis and Persistence in Mouse Embryo Fibroblasts Derived from Mice Lacking RNase L and Protein Kinase R

We report our studies to probe the possible role of the host response to double-stranded RNA in cessation of alphavirus minus-strand synthesis. Mouse embryo fibroblasts (MEF) from Mx1-deficient mice that also lack either the protein kinase R (PKR) or the latent RNase L or both PKR and RNase L were s...

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Detalhes bibliográficos
Main Authors: Sawicki, Dorothea L., Silverman, Robert H., Williams, Bryan R., Sawicki, Stanley G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140908/
https://ncbi.nlm.nih.gov/pubmed/12525614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.3.1801-1811.2003
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