Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

Lysophosphatidic acid (LPA) is a pluripotent lipid mediator acting through plasma membrane-associated LPA(x) receptors that transduce many, but not all, of its effects. We identify peroxisome proliferator-activated receptor γ (PPARγ) as an intracellular receptor for LPA. The transcription factor PPA...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	McIntyre, Thomas M., Pontsler, Aaron V., Silva, Adriana R., St. Hilaire, Andy, Xu, Yong, Hinshaw, Jerald C., Zimmerman, Guy A., Hama, Kotaro, Aoki, Junken, Arai, Hiroyuki, Prestwich, Glenn D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140905/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502787/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0135855100
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