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Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

Lysophosphatidic acid (LPA) is a pluripotent lipid mediator acting through plasma membrane-associated LPA(x) receptors that transduce many, but not all, of its effects. We identify peroxisome proliferator-activated receptor γ (PPARγ) as an intracellular receptor for LPA. The transcription factor PPA...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: McIntyre, Thomas M., Pontsler, Aaron V., Silva, Adriana R., St. Hilaire, Andy, Xu, Yong, Hinshaw, Jerald C., Zimmerman, Guy A., Hama, Kotaro, Aoki, Junken, Arai, Hiroyuki, Prestwich, Glenn D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140905/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502787/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0135855100
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