Binding of the Hepatitis C Virus E2 Glycoprotein to CD81 Is Strain Specific and Is Modulated by a Complex Interplay between Hypervariable Regions 1 and 2

The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and is presently being evaluated as an HCV vaccine candidate. HCV binds to human cells through the interaction of E2 with the tetraspanin CD81, a putative viral receptor component. We have analyzed four...

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Bibliographische Detailangaben
Hauptverfasser: Roccasecca, RosaMaria, Ansuini, Helenia, Vitelli, Alessandra, Meola, Annalisa, Scarselli, Elisa, Acali, Stefano, Pezzanera, Monica, Ercole, Bruno Bruni, McKeating, Jane, Yagnik, Asutosh, Lahm, Armin, Tramontano, Anna, Cortese, Riccardo, Nicosia, Alfredo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140892/
https://ncbi.nlm.nih.gov/pubmed/12525620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.3.1856-1867.2003
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