Varicella-Zoster Virus Open Reading Frame 21, Which Is Expressed during Latency, Is Essential for Virus Replication but Dispensable for Establishment of Latency

Varicella-zoster virus (VZV) open reading frame 21 (ORF21) is one of at least five VZV genes expressed in latently infected human and rodent ganglia. To determine whether ORF21 is required for latent and lytic infection, we deleted 99% of ORF21 from the viral genome. The ORF21 deletion mutant virus...

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Autores principales: Xia, Dongxiang, Srinivas, Shamala, Sato, Hitoshi, Pesnicak, Lesley, Straus, Stephen E., Cohen, Jeffrey I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC140846/
https://ncbi.nlm.nih.gov/pubmed/12502838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1211-1218.2003
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