Varicella-Zoster Virus Open Reading Frame 21, Which Is Expressed during Latency, Is Essential for Virus Replication but Dispensable for Establishment of Latency

Varicella-zoster virus (VZV) open reading frame 21 (ORF21) is one of at least five VZV genes expressed in latently infected human and rodent ganglia. To determine whether ORF21 is required for latent and lytic infection, we deleted 99% of ORF21 from the viral genome. The ORF21 deletion mutant virus...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Xia, Dongxiang, Srinivas, Shamala, Sato, Hitoshi, Pesnicak, Lesley, Straus, Stephen E., Cohen, Jeffrey I.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502838/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.2.1211-1218.2003
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