Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication

Suboptimal treatment of human immunodeficiency virus type 1 (HIV-1) infection with nonnucleoside reverse transcriptase inhibitors (NNRTI) often results in the rapid selection of drug-resistant virus. Several amino acid substitutions at position 190 of reverse transcriptase (RT) have been associated...

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Detalhes bibliográficos
Main Authors: Huang, Wei, Gamarnik, Andrea, Limoli, Kay, Petropoulos, Christos J., Whitcomb, Jeannette M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140843/
https://ncbi.nlm.nih.gov/pubmed/12502865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1512-1523.2003
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