Reversion of the M184V Mutation in Simian Immunodeficiency Virus Reverse Transcriptase Is Selected by Tenofovir, Even in the Presence of Lamivudine

The methionine-to-valine mutation in codon 184 (M184V) in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) confers resistance to (−)-2′-deoxy-3′-thiacytidine (3TC; lamivudine) and increased sensitivity to 9-[2-(phosphonomethoxy)propyl]a...

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Pubblicato in:	J Virol
Autori principali:	Murry, Jeffrey P., Higgins, Joanne, Matthews, Timothy B., Huang, Victoria Y., Van Rompay, Koen K. A., Pedersen, Niels C., North, Thomas W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Vaccines and Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140811/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502828/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.2.1120-1130.2003
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