Kaposi's Sarcoma-Associated Herpesvirus Induces the Phosphatidylinositol 3-Kinase-PKC-ζ-MEK-ERK Signaling Pathway in Target Cells Early during Infection: Implications for Infectivity

Human herpesvirus 8 (HHV-8) is implicated in the pathogenesis of Kaposi's sarcoma. HHV-8 envelope glycoprotein B (gB) possesses the RGD motif known to interact with integrin molecules, and HHV-8 infectivity was inhibited by RGD peptides, by antibodies against α3 and β1 integrins, and by soluble...

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Detalhes bibliográficos
Main Authors: Naranatt, Pramod P., Akula, Shaw M., Zien, Christopher A., Krishnan, Harinivas H., Chandran, Bala
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140802/
https://ncbi.nlm.nih.gov/pubmed/12502866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1524-1539.2003
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