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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

Suppressor of cytokine signaling 3 (SOCS3) binds cytokine receptors and thereby suppresses cytokine signaling. Deletion of SOCS3 causes an embryonic lethality that is rescued by a tetraploid rescue approach, demonstrating an essential role in placental development and a non-essential role in embryo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Takahashi, Yutaka, Carpino, Nick, Cross, James C., Torres, Miguel, Parganas, Evan, Ihle, James N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC140741/
https://ncbi.nlm.nih.gov/pubmed/12554639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg057
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