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Disruption of the Regulatory β Subunit of Protein Kinase CK2 in Mice Leads to a Cell-Autonomous Defect and Early Embryonic Lethality

Protein kinase CK2 is a ubiquitous protein kinase implicated in proliferation and cell survival. Its regulatory β subunit, CK2β, which is encoded by a single gene in mammals, has been suspected of regulating other protein kinases. In this work, we show that knockout of the CK2β gene in mice leads to...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Buchou, Thierry, Vernet, Muriel, Blond, Olivier, Jensen, Hans H., Pointu, Hervé, Olsen, Birgitte B., Cochet, Claude, Issinger, Olaf-Georg, Boldyreff, Brigitte
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2003
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140710/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12529396/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.3.908-915.2003
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