Disruption of the Regulatory β Subunit of Protein Kinase CK2 in Mice Leads to a Cell-Autonomous Defect and Early Embryonic Lethality

Protein kinase CK2 is a ubiquitous protein kinase implicated in proliferation and cell survival. Its regulatory β subunit, CK2β, which is encoded by a single gene in mammals, has been suspected of regulating other protein kinases. In this work, we show that knockout of the CK2β gene in mice leads to...

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Hlavní autoři: Buchou, Thierry, Vernet, Muriel, Blond, Olivier, Jensen, Hans H., Pointu, Hervé, Olsen, Birgitte B., Cochet, Claude, Issinger, Olaf-Georg, Boldyreff, Brigitte
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC140710/
https://ncbi.nlm.nih.gov/pubmed/12529396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.908-915.2003
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