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Liver-Specific Reactivation of the Inactivated Hnf-1α Gene: Elimination of Liver Dysfunction To Establish a Mouse MODY3 Model

Mice deficient in hepatocyte nuclear factor 1 α (HNF-1α) develop dwarfism, liver dysfunction, and type 2 diabetes mellitus. Liver dysfunction in HNF-1α-null mice includes severe hepatic glycogen accumulation and dyslipidemia. The liver dysfunction may appear as soon as 2 weeks after birth. Since the...

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書誌詳細
主要な著者: Lee, Ying-Hue, Magnuson, Mark A., Muppala, Vijayakumar, Chen, Shih-Shun
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC140695/
https://ncbi.nlm.nih.gov/pubmed/12529398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.923-932.2003
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