Inhibition of IκB Kinase by a New Class of Retinoid-Related Anticancer Agents That Induce Apoptosis

The transcription factor NF-κB is overexpressed or constitutively activated in many cancer cells, where it induces expression of antiapoptotic genes correlating with resistance to anticancer therapies. Small molecules that inhibit the NF-κB signaling pathway could therefore be used to induce apoptos...

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Detalhes bibliográficos
Main Authors: Bayon, Yolanda, Ortiz, Maria A., Lopez-Hernandez, Francisco J., Gao, Feng, Karin, Michael, Pfahl, Magnus, Piedrafita, F. Javier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140693/
https://ncbi.nlm.nih.gov/pubmed/12529410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.1061-1074.2003
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