Spontaneous Mutations Restore the Viability of Tick-Borne Encephalitis Virus Mutants with Large Deletions in Protein C

The capsid protein, C, of tick-borne encephalitis virus has recently been found to tolerate deletions up to a length of 16 amino acid residues that partially removed the central hydrophobic domain, a sequence element conserved among flaviviruses which may be crucial for virion assembly. In this stud...

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Autors principals: Kofler, Regina M., Leitner, Agnes, O'Riordain, Gabriel, Heinz, Franz X., Mandl, Christian W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC140642/
https://ncbi.nlm.nih.gov/pubmed/12477849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.443-451.2003
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