Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120

Alanine scanning mutagenesis was performed on monomeric gp120 of human immunodeficiency virus type 1 to systematically identify residues important for gp120 recognition by neutralizing and nonneutralizing monoclonal antibodies (MAbs) to the CD4 binding site (CD4bs). Substitutions that affected the b...

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Detalhes bibliográficos
Main Authors: Pantophlet, Ralph, Ollmann Saphire, Erica, Poignard, Pascal, Parren, Paul W. H. I., Wilson, Ian A., Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140633/
https://ncbi.nlm.nih.gov/pubmed/12477867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.642-658.2003
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