Endogenous κ-Opioid Receptor Systems Regulate Mesoaccumbal Dopamine Dynamics and Vulnerability to Cocaine

Genetic and pharmacological approaches were used to examine κ-opioid receptor (KOR-1) regulation of dopamine (DA) dynamics in the nucleus accumbens and vulnerability to cocaine. Microdialysis revealed that basal DA release and DA extraction fraction (E(d)), an indirect measure of DA uptake, are enha...

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Detalhes bibliográficos
Main Authors: Chefer, Vladimir I., Czyzyk, Traci, Bolan, Elizabeth A., Moron, Jose, Pintar, John E., Shippenberg, Toni S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Behavioral/Systems/Cognitive
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1405843/
https://ncbi.nlm.nih.gov/pubmed/15901784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0854-05.2005
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