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HEME OXYGENASE-1-DEPENDENT AND -INDEPENDENT REGULATION OF ANGIOGENIC GENES EXPRESSION: EFFECT OF COBALT PROTOPORPHYRIN AND COBALT CHLORIDE ON VEGF AND IL-8 SYNTHESIS IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS
Induction of heme oxygenase-1 (HO-1) expression can be achieved by stimulation with cobalt protoporphyrin (CoPPIX) or cobalt chloride (CoCl(2)). HO-1 has been recently implicated in regulation of angiogenesis and CoCl(2) is known to potently activate hypoxia inducible factor-1 (HIF-1) transcription...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1403815/ https://ncbi.nlm.nih.gov/pubmed/16309584 |
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