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Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations
BACKGROUND: A key problem of drug development is to decide which compounds to evaluate further in expensive clinical trials (Phase I- III). This decision is primarily based on the primary targets and mechanisms of action of the chemical compounds under consideration. Whole-genome expression measurem...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1403807/ https://ncbi.nlm.nih.gov/pubmed/16451737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-7-51 |
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