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No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly

BACKGROUND: It has been suggested that rates of protein evolution are influenced, to a great extent, by the proportion of amino acid residues that are directly involved in protein function. In agreement with this hypothesis, recent work has shown a negative correlation between evolutionary rates and...

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Auteurs principaux: Jordan, I King, Wolf, Yuri I, Koonin, Eugene V
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC140311/
https://ncbi.nlm.nih.gov/pubmed/12515583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-3-1
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