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The influence of urinary pH on the elimination of mexiletine

1 The plasma elimination half-life of mexiletine was measured in four subjects when the urine was rendered (a) acidic and (b) alkaline. 2 Urinary acidification (pH 5.0) was associated with a plasma elimination half-life of 2.8 h and 57.5% of the intravenous dose was excreted in the urine within 48 h...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kiddie, Moira A., Kaye, C. M., Turner, P., Shaw, T. R. D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1974
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1402565/
https://ncbi.nlm.nih.gov/pubmed/22454952
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