The effect of variations in urinary pH on the pharmacokinetics of diethylcarbamazine.

1 The partitioning of diethylcarbamazine (DEC) between octan-1-ol and aqueous buffer was shown to be dependent upon the pH of the buffer. 2 Buccal absorption of DEC in five subjects was shown to increase with increasing pH. 3 In view of these findings, the disposition of DEC was investigated in the...

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Библиографические подробности
Главные авторы: Edwards, G, Breckenridge, A M, Adjepon-Yamoah, K K, Orme, M L, Ward, S A
Формат: Artigo
Язык:Inglês
Опубликовано: 1981
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1401934/
https://ncbi.nlm.nih.gov/pubmed/7340883
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