A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

In budding yeast, the silent information regulator Sir2p is a nuclear NAD-dependent deacetylase that is essential for both telomeric and rDNA silencing. All eukaryotic species examined to date have multiple homologues of Sir two (HSTs), which share a highly conserved globular core domain. Here we re...

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Autors principals: Perrod, Séverine, Cockell, Moira M., Laroche, Thierry, Renauld, Hubert, Ducrest, Anne-Lyse, Bonnard, Claude, Gasser, Susan M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2001
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC140183/
https://ncbi.nlm.nih.gov/pubmed/11226170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.1.197
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