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Synthesis by High-Efficiency Liquid-Phase (HELP) Method of Oligonucleotides Conjugated with High-Molecular Weight Polyethylene Glycols (PEGs)

The chemical modification of synthetic oligonucleotides has recently been investigated to improve their pharmacological utilization. In addition to chemical alterations of the backbone and of the heterocyclic bases, their conjugation with amphiphylic moieties, such as the polyethylene glycol has bee...

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Detalhes bibliográficos
Main Authors: Bonora, GM, Zaramella, S, Veronese, FM
Formato: Artigo
Idioma:Inglês
Publicado em: Biological Procedures Online 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140118/
https://ncbi.nlm.nih.gov/pubmed/12734594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1251/bpo2
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