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Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo

Translation initiation factor 1A (eIF1A) is predicted to bind in the decoding site of the 40S ribosome and has been implicated in recruitment of the eIF2–GTP–Met-tRNA(i)(Met) ternary complex (TC) and ribosomal scanning. We show that the unstructured C-terminus of eIF1A interacts with the C-terminus...

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Udgivet i:EMBO J
Principais autores: Olsen, DeAnne S., Savner, Erin M., Mathew, Amy, Zhang, Fan, Krishnamoorthy, Thanuja, Phan, Lon, Hinnebusch, Alan G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140105/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12514125/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg030
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