Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9–AdoMet
The methylation of lysine residues of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Here, we report two crystal structures of SET7/9, a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-l-me...
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| Veröffentlicht in: | EMBO J |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2003
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140100/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12514135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg025 |
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