Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9–AdoMet

The methylation of lysine residues of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Here, we report two crystal structures of SET7/9, a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-l-me...

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Опубликовано в::	EMBO J
Главные авторы:	Kwon, Taewoo, Chang, Jeong Ho, Kwak, Eunyee, Lee, Chang Wook, Joachimiak, Andrzej, Kim, Young Chang, Lee, Jaewoon, Cho, Yunje
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2003
Предметы:	Articles
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140100/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12514135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg025
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