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Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney
Mice lacking exon 3 of perlecan (Hspg2) gene were generated by gene targeting. Exon deletion does not alter the expression or the reading frame but causes loss of attachment sites for three heparan sulfate (HS) side chains. Hspg2(Δ)(3/)(Δ)(3) mice are viable and fertile but have small eyes. Apoptosi...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140094/ https://ncbi.nlm.nih.gov/pubmed/12514129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg019 |
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