Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Cardiac failure is a frequent cause of death in the aging human population. Telomere attrition occurs with age, and is proposed to be causal for the aging process. To determine whether telomere shortening leads to a cardiac phenotype, we studied heart function in the telomerase knockout mouse, Terc–...

Full beskrivning

Bibliografiska uppgifter

I publikationen:	EMBO J
Huvudupphov:	Leri, Annarosa, Franco, Sonia, Zacheo, Antonella, Barlucchi, Laura, Chimenti, Stefano, Limana, Federica, Nadal-Ginard, Bernardo, Kajstura, Jan, Anversa, Piero, Blasco, María A.
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Publishing Group 2003
Ämnen:	Articles
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12505991/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg013
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!