Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Cardiac failure is a frequent cause of death in the aging human population. Telomere attrition occurs with age, and is proposed to be causal for the aging process. To determine whether telomere shortening leads to a cardiac phenotype, we studied heart function in the telomerase knockout mouse, Terc–...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Leri, Annarosa, Franco, Sonia, Zacheo, Antonella, Barlucchi, Laura, Chimenti, Stefano, Limana, Federica, Nadal-Ginard, Bernardo, Kajstura, Jan, Anversa, Piero, Blasco, María A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12505991/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg013
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