Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Cardiac failure is a frequent cause of death in the aging human population. Telomere attrition occurs with age, and is proposed to be causal for the aging process. To determine whether telomere shortening leads to a cardiac phenotype, we studied heart function in the telomerase knockout mouse, Terc–...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Leri, Annarosa, Franco, Sonia, Zacheo, Antonella, Barlucchi, Laura, Chimenti, Stefano, Limana, Federica, Nadal-Ginard, Bernardo, Kajstura, Jan, Anversa, Piero, Blasco, María A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2003
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC140062/
https://ncbi.nlm.nih.gov/pubmed/12505991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg013
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