Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Cardiac failure is a frequent cause of death in the aging human population. Telomere attrition occurs with age, and is proposed to be causal for the aging process. To determine whether telomere shortening leads to a cardiac phenotype, we studied heart function in the telomerase knockout mouse, Terc–...

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Autori principali: Leri, Annarosa, Franco, Sonia, Zacheo, Antonella, Barlucchi, Laura, Chimenti, Stefano, Limana, Federica, Nadal-Ginard, Bernardo, Kajstura, Jan, Anversa, Piero, Blasco, María A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC140062/
https://ncbi.nlm.nih.gov/pubmed/12505991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg013
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