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Pro-inflammatory Effects of Bacterial Recombinant Human C-Reactive Protein are Caused by Contamination with Bacterial Products not by C-Reactive Protein Itself

Intravenous administration to human volunteers of a commercial preparation of recombinant human C-reactive protein (CRP) produced in E. coli was recently reported in this journal to induce an acute phase response of serum amyloid A protein (SAA) and of CRP itself, and to activate the coagulation sys...

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Bibliografiske detaljer
Main Authors: Pepys, Mark B., Hawkins, Philip N., Kahan, Melvyn C., Tennent, Glenys A., Gallimore, J. Ruth, Graham, David, Sabin, Caroline A., Zychlinsky, Arturo, de Diego, Juana
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1400607/
https://ncbi.nlm.nih.gov/pubmed/16254214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000193595.03608.08
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