Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3′-phosphoglycolate, 5′-phosphate gapped lesion

Bleomycins (BLMs) are antitumor antibiotics that in the presence of iron and oxygen mediate DNA damage by 4′-hydrogen atom abstraction of pyrimidines 3′ to guanines. The resulting 4′-deoxyribose radicals can be trapped by O(2) and ultimately result in the formation of base-propenal and gapped DNA wi...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Junker, Hans-Dieter, Hoehn, Silvia T., Bunt, Richard C., Marathius, Vasilios, Chen, Jingyang, Turner, Christopher J., Stubbe, JoAnne
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 2002
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140059/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12490718/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf681
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