Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3′-phosphoglycolate, 5′-phosphate gapped lesion

Bleomycins (BLMs) are antitumor antibiotics that in the presence of iron and oxygen mediate DNA damage by 4′-hydrogen atom abstraction of pyrimidines 3′ to guanines. The resulting 4′-deoxyribose radicals can be trapped by O(2) and ultimately result in the formation of base-propenal and gapped DNA wi...

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Hauptverfasser: Junker, Hans-Dieter, Hoehn, Silvia T., Bunt, Richard C., Marathius, Vasilios, Chen, Jingyang, Turner, Christopher J., Stubbe, JoAnne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140059/
https://ncbi.nlm.nih.gov/pubmed/12490718
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