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Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3′-phosphoglycolate, 5′-phosphate gapped lesion
Bleomycins (BLMs) are antitumor antibiotics that in the presence of iron and oxygen mediate DNA damage by 4′-hydrogen atom abstraction of pyrimidines 3′ to guanines. The resulting 4′-deoxyribose radicals can be trapped by O(2) and ultimately result in the formation of base-propenal and gapped DNA wi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140059/ https://ncbi.nlm.nih.gov/pubmed/12490718 |
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