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Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI(+)]

The yeast prion [PSI(+)] provides an epigenetic mechanism for the inheritance of new phenotypes through self-perpetuating changes in protein conformation. [PSI(+)] is a nonfunctional, ordered aggregate of the translation termination factor Sup35p that influences new Sup35 proteins to adopt the same...

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Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Liu, Jia-Jia, Sondheimer, Neal, Lindquist, Susan L.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 2002
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139907/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12461168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252652099
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