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Interactions among prions and prion “strains” in yeast

Prions are “infectious” proteins. When Sup35, a yeast translation termination factor, is aggregated in its [PSI(+)] prion form its function is compromised. When Rnq1 is aggregated in its [PIN(+)] prion form, it promotes the de novo appearance of [PSI(+)]. Heritable variants (strains) of [PSI(+)] wit...

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Bibliografiske detaljer
Main Authors: Bradley, Michael E., Edskes, Herman K., Hong, Joo Y., Wickner, Reed B., Liebman, Susan W.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139899/
https://ncbi.nlm.nih.gov/pubmed/12149514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152330699
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