Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α

The molecular chaperone HSP90 regulates stability and function of multiple protein kinases. The HSP90-binding drug geldanamycin interferes with this activity and promotes proteasome-dependent degradation of most HSP90 client proteins. Geldanamycin also binds to GRP94, the HSP90 paralog located in th...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Marcu, Monica G., Doyle, Melissa, Bertolotti, Anne, Ron, David, Hendershot, Linda, Neckers, Len
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2002
Konular:
Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC139892/
https://ncbi.nlm.nih.gov/pubmed/12446770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.24.8506-8513.2002
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller