The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

The proinflammatory cytokine tumor necrosis factor alpha (TNF-α) regulates immune responses, inflammation, and programmed cell death (apoptosis). TNF-α exerts its biological activities by activating multiple signaling pathways, including IκB kinase (IKK), c-Jun N-terminal protein kinase (JNK), and c...

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Bibliographic Details
Main Authors: Tang, Fangming, Tang, Guilin, Xiang, Jialing, Dai, Qing, Rosner, Marsha R., Lin, Anning
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC139858/
https://ncbi.nlm.nih.gov/pubmed/12446776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.24.8571-8579.2002
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