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Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

Interleukin-1 (IL-1) receptor-associated kinase (IRAK) plays an important role in the sequential formation and activation of IL-1-induced signaling complexes. Previous studies showed that IRAK is recruited to the IL-1-receptor complex, where it is hyperphosphorylated. We now find that the phosphoryl...

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Udgivet i:Mol Cell Biol
Principais autores: Jiang, Zhengfan, Ninomiya-Tsuji, Jun, Qian, Youcun, Matsumoto, Kunihiro, Li, Xiaoxia
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139807/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242293/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.20.7158-7167.2002
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