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Mechanism of E47-Pip Interaction on DNA Resulting in Transcriptional Synergy and Activation of Immunoglobulin Germ Line Sterile Transcripts

E47 and Pip are proteins crucial for proper B-cell development. E47 and Pip cooperatively bind to adjacent sites in the immunoglobulin kappa chain 3′ enhancer and generate a potent transcriptional synergy. We generated protein-DNA computer models to visualize E47 and Pip bound to DNA. These models p...

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Udgivet i:Mol Cell Biol
Principais autores: Nagulapalli, Sujatha, Goheer, Aisha, Pitt, Leslie, McIntosh, Lawrence P., Atchison, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139794/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242308/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.20.7337-7350.2002
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