Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides

When targeted to sequences adjacent to a TATA element, pyrrole-imidazole (Py-Im) polyamides inhibit the DNA binding activity of TATA box binding protein (TBP) and basal transcription by RNA polymerase II. In the present study, we scanned the human immunodeficiency virus type 1 promoter for polyamide...

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Bibliographic Details
Main Authors: Ehley, Jennifer A., Melander, Christian, Herman, David, Baird, Eldon E., Ferguson, Heather A., Goodrich, James A., Dervan, Peter B., Gottesfeld, Joel M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135605/
https://ncbi.nlm.nih.gov/pubmed/11865052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.6.1723-1733.2002
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